Archive for the 'research' Category

$2.5 million study of diet to treat CD

Well I’ll be damned.

For the first time ever, dietary intervention will be the focus of a major national research study of patients with Crohn’s disease. The Crohn’s & Colitis Foundation of America (CCFA) announced today that it was awarded $2.5 million from the Patient-Centered Outcomes Research Institute (PCORI) to study the effectiveness of the specific carbohydrate diet and Mediterranean-style diet to induce remission in patients with Crohn’s disease.

It will compare the effectiveness of the SCD and a Mediterranean style diet.

Seriously, I never thought I’d see something like this.

Here’s your link.

Novel mechanism for Crohn’s disease uncovered

Researches at the Technische Universität München have shown in a mouse model that bacterial imbalance in the gut can lead to a Chrohn’s-like inflammation. Previously, it was not know wether an unbalanced gut microbiota was the cause or result of inflammation. Their research shows that it is the cause. Here’s your link.

Crohn’s disease bacterial profile revealed

Article From Scientific American:

The largest study of its kind has revealed for the first time the specific gut bacteria involved in Crohn’s disease, which afflicts an estimated 700,000 Americans with chronic, painful diarrhea and bleeding, among other unpleasant symptoms. With a better understanding of how the microbial ecosystem changes in children who suffer from the disease, researchers have gained clues that could someday lead to better diagnosis and treatment.

Here’s your link.

CCFA releases “Challenges in IBD Research”

CCFA_IBD_journal

The Crohn’s and  Colitis Foundation of America has released it’s latest “Challenges in IBD Research” It is from their official journal and is entitled “Update on Progress and Prioritization of the CCFA’s Research Agenda“. Unfortunately, most of the content of this site is behind a paywall, but this particular report is free.

UCD report: Nitrate helps fuel the flame of IBD

UC Davis

A report from UC Davis Health System links nitrate produced by gut inflammation to E. coli growth, crowding out good bacteria, and contributing to the inflammatory process.

In test-tube and animal studies, the researchers found that potentially harmful bacteria in the intestine called Enterobacteriaceae use nitrate — a byproduct formed during the intestinal inflammation in IBD — to grow and thrive. Enterobacteriaceaestrains include certain E. coli bacteria, which can worsen the intestinal damage of IBD. Eventually, the intestines of those with IBD become overrun by harmful bacteria, and the numbers of normal good bacteria in the gut decrease.

Here’s your link.

uBiome – get your microbiome sequenced

This looks interesting:

Be a citizen scientist and help us sequence the human microbiome. Learn about your health, advance science, and CHANGE THE WORLD!

Here’s your link.

Specific bacterial species may initiate, maintain Crohn’s

From the study:

Patients newly diagnosed with pediatric Crohn’s disease had significantly different levels of certain types of bacteria in their intestinal tracts than age-matched controls, according to a paper in the October Journal of Clinical Microbiology. The work may ultimately lead to treatment involving manipulation of the intestinal bacteria.

Here’s the link to an easy to read version. And here’s your link to the actual study report.

Thanks to Ryan Jordan on Facebook. You should get Ryan’s posts on your feed as he’s really on top of research and news on Crohn’s.


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